I have found that it is easy to make changes to CMS for a site and then realise that they were made to the wrong site.
Sometimes admin loads site 1 when you think you are working on site 2 (or 3 etc) - so you make changes and then have to retrace and undo.
One solution to guard against this is to create a unique banner for the admin for each domain. Having done this it is now clear which site I am working on.
Hope this is useful?